SBE-β-CDisasulfobutyletherβ-cyclodextrinderivative,itisanexcipientoraformulatingagentusedtoincreasethesolubilityofpoorlysolubledrugs.

SBE-β-CDisachemicallymodifiedβ-CDthatisacyclichydrophilicoligosaccharidewhichisnegativelychargedinaqueousmedia.β-CDfunctionedisasolubilizeronlyatlowconcentrations,whereasSBE7-β-CDexhibitsstrongsolubilizingeffectsoverawideconcentrationrange^[1].

SBE-β-CDisaderivatizedformofβ-cyclodextrinthathasbeendevelopedasasafeandeffectivesolubilizingagentfordrugsbeingadmiNISTeredbyparenteralandotherroutes(includingoral).SBE-β-CDisacycliccarbohydratecomprisedofsevenglucosemolecules;theresultingtruncatedcone-likestructurebeingfurtherderivatizedwithanaverageofsevensulfobutylethergroups^[2].ThecalorimetricdatafortheCompound1/SBE-β-CDcomplexindicatesanextremelystronginteraction,withanassociationconstantof2.3±(0.2)×10⁶M^-1at25°Cand1.6±(0.2)×10⁶M^-1at37°C^[3].SBE-β-CDaloneevokesamildcardio-depressanteffectindependentofcocainetreatment(p=0.0001comparedtobaseline)butattenuatesfurthercocaine-induceddecreasesinRPP,dP/dtmax,anddP/dtmax_absathighcocaineconcentrations.NosignificanteffectisseenonlinepressureSBE-β-CDalleviatesthemostpronouncedcardiacdepressionforRPP,dP/dtmax,anddP/dtmax_abs.ThisdifferentialeffectofSBE-β-CDatlowandhighconcentrationsproducesaninteractioneffectinthetwo-wayANOVAforRPP(p<0.0001), dp/dtmax="" (p="0.0001)," and="">_abs(p=0.0015),andpreventsanyoveralltreatmenteffect.InfusingSBE-β-CDalsoattenuatesthecardiacdepressionassociatedwithcocaethylenetoxicityforRPPanddP/dtmax.Nodifferencesareobservedbetweenethanol-treatedcontrolsandcocaethyleneplusSBE-β-CDgroups^[4].

• [1].FukudaM,etal.Influenceofsulfobutyletherbeta-cyclodextrin(Captisol)onthedissolutionpropertiesofapoorlysolubledrugfromextrudatespreparedbyhot-meltextrusion.IntJPharm.2008Feb28;350(1-2):188-196.

  [2].LockwoodSF,etal.Improvedaqueoussolubilityofcrystallineastaxanthin(3,3"-dihydroxy-beta,beta-carotene-4,4"-dione)byCaptisol(sulfobutyletherbeta-cyclodextrin).JPharmSci.2003Apr;92(4):922-926.

  [3].CharmanSA,etal.Alterationoftheintravenouspharmacokineticsofasyntheticozonideantimalarialinthepresenceofamodifiedcyclodextrin.JPharmSci.2006Feb;95(2):256-67.

  [4].FettiplaceMR,etal.Cardiacdepressioninducedbycocaineorcocaethyleneisalleviatedbylipidemulsionmoreeffectivelythanbysulfobutylether-β-cyclodextrin.AcadEmergMed.2015May;22(5):508-17.

SBE-β-CDispreparedinsaline^[3].

Rat^[3]
A300gratisadministeredwith1mLofa0.1MSBE-β-CDsolutioncontaining5.64mgofCompound1,andassuminganextracellularvolumeof90mL,lessthan0.1%ofthecomplexwouldrapidlydissociateduetotheinitialeffectsofdilution.Thiscalculation,combinedwiththechangingbloodtoplasmaratiointhepresenceofSBE-β-CD,providesareasonableexplanationfortheobserveddifferencesinthebloodandplasmaprofilesofCompound1afterintravenousadministrationineitherthecyclodextrinorcyclodextrin-freeformulations.AfterIVadministrationofthecyclodextrinformulation,Compound1wouldinitiallybepreventedfromdistributingintoerythrocytestherebyresultinginawholebloodtoplasmaratiooflessthanone.Subsequently,clearanceofSBE-β-CDfromthecirculationwouldleadtochangesinthecomplexationequilibriumsuchthattheunboundfractionofCompound1wouldincrease,therebyreestablishingnormalbloodtoplasmapartitioning(i.e.infavourofwholeblood)andclearance.MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.

• [1].FukudaM,etal.Influenceofsulfobutyletherbeta-cyclodextrin(Captisol)onthedissolutionpropertiesofapoorlysolubledrugfromextrudatespreparedbyhot-meltextrusion.IntJPharm.2008Feb28;350(1-2):188-196.

  [2].LockwoodSF,etal.Improvedaqueoussolubilityofcrystallineastaxanthin(3,3"-dihydroxy-beta,beta-carotene-4,4"-dione)byCaptisol(sulfobutyletherbeta-cyclodextrin).JPharmSci.2003Apr;92(4):922-926.

  [3].CharmanSA,etal.Alterationoftheintravenouspharmacokineticsofasyntheticozonideantimalarialinthepresenceofamodifiedcyclodextrin.JPharmSci.2006Feb;95(2):256-67.

  [4].FettiplaceMR,etal.Cardiacdepressioninducedbycocaineorcocaethyleneisalleviatedbylipidemulsionmoreeffectivelythanbysulfobutylether-β-cyclodextrin.AcadEmergMed.2015May;22(5):508-17.

1451.29

C₅₀H₈₄Na₂O₄₁S₂

182410-00-0

4°C,protectfromlight

RoomtemperatureincontinentalUS;mayvaryelsewhere

H₂O:≥33mg/mL;DMSO:5.625mg/mL

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:>98.0%

SelectBatch:HY-17031-22981HY-17031-22970HY-17031-26609HY-17031-24580HY-17031-20021

DataSheet(130KB)SDS(389KB)

COA(102KB)

HandlingInstructions(1252KB)

• [1].FukudaM,etal.Influenceofsulfobutyletherbeta-cyclodextrin(Captisol)onthedissolutionpropertiesofapoorlysolubledrugfromextrudatespreparedbyhot-meltextrusion.IntJPharm.2008Feb28;350(1-2):188-196.

  [2].LockwoodSF,etal.Improvedaqueoussolubilityofcrystallineastaxanthin(3,3"-dihydroxy-beta,beta-carotene-4,4"-dione)byCaptisol(sulfobutyletherbeta-cyclodextrin).JPharmSci.2003Apr;92(4):922-926.

  [3].CharmanSA,etal.Alterationoftheintravenouspharmacokineticsofasyntheticozonideantimalarialinthepresenceofamodifiedcyclodextrin.JPharmSci.2006Feb;95(2):256-67.

  [4].FettiplaceMR,etal.Cardiacdepressioninducedbycocaineorcocaethyleneisalleviatedbylipidemulsionmoreeffectivelythanbysulfobutylether-β-cyclodextrin.AcadEmergMed.2015May;22(5):508-17.

品牌介绍

Medchemexpress（MCE）

• 图文详情
 
• 属性
•  

MedChemexpress（MCE）是全球＊＊的科研化学品和生物活性化合物供应商，总部位于美国新泽西。 我们的产品范围覆盖各种抑制剂、激动剂、API和化合物库。专业、**的企业灵魂铸造了MCE的行业地位。热情和充满活力的研发团队拥有着大量的化学和生物科学家。MCE专注于生物活性化合物，拥有着多年的发展历程和丰富的行业经验。从产品的HNMR数据解析到生物活性数据，从客户的询价到产品的售后服务，我们拥有着完善的管理体系，从而保证我们的服务更加**、准确。MCE(中国)，努力为中国的医药行业发展注入新的活力，我们将成为您研发工作值得信赖的伙伴。

公司介绍

更多...

Medchemexpress（MCE） 图文详情  

产品分类

更多...

Flavonoids Inhibitory Antibodies Phenylpropanoids Acids and Aldehydes Quinones Peptides Others Phenols Terpenoids and Glycosides Steroids Alkaloid Saccharides and Glycosides Dye Reagents Biochemical Assay Reagents

销售排行

更多...

Medchemexpress/Plerixafor octahydrochloride(Synonyms: AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydroch

$84.00

Medchemexpress/GSK126(Synonyms: EZH2 inhibitor; GSK2816126A)/HY-13470/50mg

$83.00

Medchemexpress/MLN4924(Synonyms: Pevonedistat)/HY-70062/5mg

$117.00

Medchemexpress/Cyclosporin A(Synonyms: Cyclosporine; Ciclosporin)/HY-B0579/10mM*1mL in DMSO

$66.00

Medchemexpress/(-)-Blebbistatin(Synonyms: (S)-(-)-Blebbistatin)/HY-13441/5mg

$79.00

Medchemexpress/Riociguat(Synonyms: BAY 632521)/HY-14779/200mg

$79.00

Medchemexpress/H-89 dihydrochloride(Synonyms: Protein kinase inhibitor H-89 dihydrochloride)/HY-15979A/100mg

$74.00

Medchemexpress/WIN 55,212-2 Mesylate(Synonyms: (R)-(+)-WIN 55212)/HY-13291/10mM*1mL in DMSO

$69.00

问答列表

更多...

MCE公司,MedChemExp代理商,MedChemExpress经销商,MCE厂家... 科普:武汉品牌试剂实验MedChemExp代理 MedChemExp授权,哪里有卖? 有谁知道北京华奥汽车服务有限公司怎么样? 氯化钡分析纯500g 氯化钡分析纯500g批发价格、市场报价、厂家... 科普:武汉品牌试剂实验MedChemExp代理 MedChemExp授权,哪里有卖? 兔抗人TIGAR蛋白抗体_价格_上海信裕生物技术有限公司 融合蛋白化学降解实验——用溴化氰资讯

厂家直采

全球直采 正品优价

正品保障

厂家直发 有线跟踪

正规清关

CIF100%正规报关，提供发票

及时交付

限时必达 不达必赔

快速导航：

公司介绍

产品中心

新闻动态

在线咨询

联系我们

公司介绍

产品中心

新闻动态

在线咨询

联系我们

总部地址：

江苏省苏州市工业园区星湖街218号 苏州生物医药产业园一期（生物纳米园）A4-216(邮编：215125)

工作时间：周一至周五9:00~18:00

技术支持：

Email：info@ebiomall.com

短信：18915418616

服务热线：

4000-520-616（全国）

☏  0512-67156496（苏州）

版权信息：

©  2015- 苏州蚂蚁淘生物科技有限公司 版权所有 中国

网站备案：

苏ICP备17049038号-1

苏公网安备 32059002001627号

友情链接：

联系QQ:764052152

medix代理商 medkoo促销 megazyme现货 microspheres公司 midlandsci试剂抗体 minerva molecular molinnov moltox mpbio

免责声明：

本站有部分内容来自互联网，如无意中侵犯了某个媒体 、公司 、企业或个人等的知识产权，请来电或致函告之，
本网站将在规定时间内给予删除等相关处理。

扫描二维码关注官方微信

获取最新促销及产品信息