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主营:抑制剂、激动剂、API
℡ 4000-520-616
℡ 4000-520-616
Medchemexpress/Ceruletide(Synonyms: Caerulein; Cerulein)/HY-A0190/10mM*1mL in Water
产品编号:HY-A0190-1mg
市  场 价:¥3200.00
场      地:美国(厂家直采)
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Medchemexpress/Ceruletide(Synonyms: Caerulein; Cerulein)/HY-A0190/10mM*1mL in Water
商品介绍
Ceruletide(Caerulein)isaBIOLOGicallyactivedecapeptideisolatedfromtheskinoftheAustralianfrogHylacaerulea.Itisapotentcholecystokineticagentwithadirectspasmogeniceffectonthegallbladdermuscleandbileductsinhumansand
Description

Ceruletide(Caerulein)isabiologicallyactivedecapeptideisolatedfromtheskinoftheAustralianfrogHylacaerulea.Itisapotentcholecystokineticagentwithadirectspasmogeniceffectonthegallbladdermuscleandbileductsinhumansand

InVitro

Ceruletideissimilarchemicallyandbiologicallytothehumangastrointestinalhormonescholecystokinin-pancreozymin(CCK)andgastrinII.Ceruletidestimulatesgallbladdercontraction,pancreaticexocrinesecretion,gastricsecretion,andmotilityinthedistalduodenum,jejunum,ileumandcolon,whiledelayinggastricemptyingandinhibitingmotilityintheproximalduodenum[1].NF-kappaB/Relisrapidlyactivatedduringceruleinpancreatitis.Thisactivationmayinduceaself-defendinggeneticprogrambeforetheonsetofcellularinjury,whichmightpreventhigherdegreesofdamageofpancreaticacinarcellsaftersecretagoguehyperstimulation[2].

References
  • [1].VincentME,etal.Pharmacology,clinicaluses,andadverseeffectsofceruletide,acholecystokineticagent.Pharmacotherapy.1982Jul-Aug;2(4):223-34.

    [2].SteinleAU,etal.NF-kappaB/Relactivationinceruleinpancreatitis.Gastroenterology.1999Feb;116(2):420-30.

MolecularWeight

1352.41

Formula

C₅₈H₇₃N₁₃O₂₁S₂

CASNo.

17650-98-5

Storage
Powder-80°C2years
 -20°C1year
Insolvent-80°C6months
 -20°C1month
Shipping

RoomtemperatureincontinentalUS;mayvaryelsewhere

Solvent&Solubility

H2O:≥100mg/mL

*"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation="">

Purity:99.59%